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HPLC Method to Differentiate Four THC Stereoisomers Formed from Δ9-THC Degradation: (6aR,9R)-Δ10-THC, (6aR,9S)-Δ10-THC, 9(R)-Δ6a,10a-THC, and 9(S)-Δ6a,10a-THC

Key Features

  • Δ10-THC and Δ6a,10a-THC isomers produced from Δ9-THC degradation have stereochemical similarities that are challenging to differentiate.
  • Traditional reversed-phase (C18) HPLC analysis is not suitable for accurate determination of these isomers.
  • A method using a chiral HPLC column under normal-phase conditions offers reliable and robust identification of the four stereoisomers.
  • Use of a chiral HPLC stationary phase for characterization of these phytocannabinoid degradants is an essential tool for the determination of potency and safety.
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