Purification of CBD Extracts using SFC and a Celeris™ 4-Ethyl Pyridine Column

Introduction

In recent years, there has been a growing interest in the development of therapies and other consumer products derived from cannabis and/or hemp, including cannabidiol (CBD). With the passage of the US 2018 Farm Bill, hemp was removed from the Controlled Substances Act (CSA), which means that cannabis plants and derivatives that contain no more than 0.3 percent Tetrahydrocannibinol (THC) on a dry weight basis are no longer controlled substances under federal law. The small amount of THC found naturally in hemp plants can sometimes exceed the legal limit of 0.3% when extracted and concentrated along with the CBD. Therefore, it is important to have a means of removing the THC from CBD extracts in order to comply with Federal regulations.