Quantitative LC-UV Method for CBD in Topicals with Simplified Extraction of Lotions, Balms, and Creams

A universal extraction method has been developed for the LC-UV analysis of cannabidiol (CBD) in infused lotions, balms, and creams. The method was evaluated using fortified samples with percent recoveries ranging from 90.2–108%. Linearity was evaluated from 2–300 ppm and returned an R2 value of 0.9997. The sample preparation methods developed here produce clean extracts and reliable results. The LC-UV analysis was conducted using a Raptor ARC-18 (150 mm x 4.6 mm ID x 2.7 µm) column with a Raptor ARC-18 EXP guard column cartridge. Isocratic mobile phase conditions were used for a total run time of five minutes per sample.