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Research & Development Medical research

Gut Reaction

Endocannabinoids modulate gut biology and appear to protect mice from becoming ill with certain "stomach bugs" (enteric bacteria) according to a new paper out in biology journal Cell (1). Researchers focused on an endocannabinoid called 2-arachidonoyl glycerol (2-AG) and found that it blocks virulence pathways in enteric bacteria; specifically, the bacterial QseC receptor.

Mice with elevated 2-AG (whether caused by genetics or drug treatment) had fewer symptoms and recovered faster than control mice. The researchers hope the findings might lead to new options for hard-to-treat infections in humans, such as drug-resistant E. coli. 

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  1. M Ellermann et al., Cell [Online ahead of print] (2020). DOI: 10.1016/j.cell.2020.09.022
About the Author
Charlotte Barker

Associate Content Director

After studying biology at Imperial College London, I got my start in biomedical publishing as a commissioning editor for healthcare journals, and I’ve spent my career covering everything from early-stage research to clinical medicine. Attracted by the creativity, talent and passion of the team, I joined Texere Publishing in 2014, where I’m now Associate Content Director and Editor of The Cannabis Scientist.

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