Cookies

Like most websites The Cannabis Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Testing & Processing Cannabinoid analysis, Mycotoxin analysis, Pesticide analysis

Quantitative Analysis of THC and its Metabolites in Plasma Using Oasis PRiME HLB for Toxicology and Forensic Laboratories

Introduction

Amongst forensic toxicology laboratories, cannabis is one of the most frequently encountered drugs.1 For most forensic laboratories providing toxicological analyses, the confirmation, and quantification of Δ9-tetrahydrocannabinol (THC) and its primary metabolites in whole blood or plasma is high on the list of requests from clients and enforcement agencies, such as district attorneys and/or police departments (city, county, or state levels).2 While whole blood is often used in postmortem forensic cases, whole blood/plasma ratios can be quite inconsistent, particularly for COOH-THC.3 Therefore, for pharmacokinetic studies involving medicinal uses or behavioral effects, plasma is often a preferred matrix.4,5 The ability to efficiently extract and quickly analyze samples submitted by such agencies is seen as a definite benefit to the laboratory. In this application, the efficient extraction and accurate quantification of THC and two major metabolites, THC-COOH and THC-OH, is achieved using a novel solid-phase extraction (SPE) sorbent, Oasis PRiME HLB, coupled with fast analysis using LC-MS/MS. This method offers a great solution for laboratories looking to incorporate this type of analysis into their methodology portfolio.

Read the full article now

Log in or register to read this article in full and gain access to The Cannabis Scientist’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Cannabis Scientist magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

Register to The Cannabis Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Cannabis Scientist magazine

Register